The Impact of short and long-term physical activity on the change in the number

 

The effect of short – and long-term physical activity on the change in the number of sugar content in various tissues of 6 – and 12 – month animals before and after ionizing radiation

The problem of studying of mechanisms of influence of ionizing radiation on the organism of animals and humans is very important as at the present stage and the future of science. There are two types of human exposure: external and internal. External exposure is the exposure that comes from external sources (cosmic radiation, the radiation that comes from radioactive substances in the soil, etc.), internal radiation is radiation in which radioaktivnie substances can get inside the human body with food and water and dust when breathing ionization leads to the destruction of vital substances in living cells, including DNA molecules, in which encoded hereditary human code. A violation arising under the action of ionizing radiation in cells of various organs, leading to the emergence of various diseases, in particular for the formation of malignant tumors and, at high doses, death. Therefore, we aim to examine the effect of 10 – and 60-minute physical activity on the change in the number of sugar content in various tissues of the 180 and 364 day animals before and after ionizing radiation. From the obtained experimental data, it is clear that after effects 10 minute physical activity the amount of sugar content in various tissues such as the 180 and 364 day animals increases; with 60-minute physical exercise, the amount of sugar content in various tissues decreases. After effect 200 and 700 x-ray doses of ionizing radiation and 10, 60 min. physical activity the nature of carbohydrate metabolism in 180 and 364 day animals, depending on the age ranges varied (table 1, 2).

Materials and methods

The experiments were conducted on linear rats breed “Wistar” weighing 200-300 grams of various age groups contained in standard conditions of vivarium. Irradiation of animals was performed using the ROOM-11 to 2 and 7 Grams each irradiation.

The experiments were carried out in the next series.

1. Determination of the amount of sugar content in various tissues 180 and 364 – day animals.

2. Determination of the amount of sugar content at 180 and 364 – day-old animals after short – and long-term physical activity.

3. Determination of the amount of sugar content in various tissues 180 and 364 day animals after effects of ionizing radiation.

4. Studied the effect of short – and long-term physical activity before and after ionizing radiation in changing the level of sugar content in various tissues 180 and 364 day animals.

Conditions of the experience: voltage 180 kV, current 20 mA, the thickness of the filter is 0.5 mm, the duration of the background between the animal and rentgenski apparatus 30 cm, the total dose was 120 minutes R. The sugar content in the homogenate obtained from various tissues was determined by the method of Hagedorn-Jensen (1923), Z. I. Tohno and others (1981).

The experiments were performed on control and experimental animals through 1,5,10,15,20,25,30 days before and after irradiation under the influence of short-term physical activity of the rats swam in the bath 10 min. at long-term physical activity 60 min.

As can be seen from table 1, the level of sugar in various tissues of the 180 day white rats in the brain is a maximum of 115 mg%, at least 109 mg% in blood a maximum of 125 mg%, at least 117 mg%, in the kidneys to a maximum of 175 mg%, at least 161 mg%, and in diurnal animals in the brain was a maximum of 130 mg%, a minimum of 124 mg% in blood a maximum of 125 mg%, at least 118 mg%, in the kidneys to a maximum of 181 mg%, at least 174 mg%. As seen from the data obtained in intact animals the sugar content in the tissues of the kidneys and in the blood as the 180 day and 364 day animals more than in the brain tissue.

As can be seen from table 1, 180 animals of the day after effect of short-time physical activity, compared with intact animals, the sugar content (in the brain tissues of 12%, in the blood by 17%, in the kidney 18%) increased. Physical activity, compared with the normal sugar content in the brain tissue (9% blood 8%, in the kidney 9%) decreased. These changes have also been observed in 180 animals of the day. As seen from table 1, 2, after determining the sugar content in the tissues of normal animals were exposed to radiation at doses of 200 and 700 x-rays. Through 1, 5, 10, 15, 20, 25, 30 days after ionizing radiation was determined by the sugar content in various tissues of both short-and long-term physical activity. After 1, 5, 10, 15 days after ionizing radiation the sugar content in various tissues, compared to normal like 180 and 364 day animals is greatly increased, and in 20, 25 and 30 days after physical exercise, on the contrary, is significantly reduced.

At 180 and 364 day white rats after 25 and 30 days after ionizing irradiation, most rats die because irradiation causes a decrease in the activity of enzymes involved in glucose metabolism.

From literature (4, 5, 7) and our data (1, 3, 6, 8) it is seen that, both in normal and irradiated animals in the regulation of sugar content in various tissues involved the hypothalamic-pituitary-adrenal system.

From research in this field of research, viewlink that (1, 6, 8, 12) after action of low and lethal doses of radiation x-radiation, is a deep change of enzymes involved in glucose metabolism in lipid oxidation and activity of acetylcholine.

The effect of exercise (F. N.) before and after ionizing radiation (IR) on the level change amount of the sugar content in various tissues 180 day white rats in postnatal ontogenesis (mg%, ml) m+M: n=8

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